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A vein wall cell atlas of murine venous thrombosis determined by single-cell RNA sequencing

31 Jan 2023

Abstract excerpt

Deep vein thrombosis (DVT) is a common clinical problem, but its cellular and molecular mechanisms remain incompletely understood. In this study, we performed single-cell RNA sequencing on mouse inferior vena cava (IVC) 24 h after thrombus-inducing IVC ligation or sham operation. 9 cell types composed of multiple subpopulations were identified. Notable transcriptomic changes induced by DVT included a marked...

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PMID: 36721040
DOI: 10.1038/s42003-023-04492-z

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