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Article

Folding of the Cerebral Cortex Requires Cdk5 in Upper-Layer Neurons in Gyrencephalic Mammals.

Cell reports - 29 Aug 2017

Shinmyo Yohei, Terashita Yukari, Dinh Duong Tung Anh, Horiike Toshihide, Kawasumi Muneo, Hosomichi Kazuyoshi, Tajima Atsushi, Kawasaki Hiroshi

Abstract excerpt

Folds in the cerebral cortex in mammals are believed to be key structures for accommodating increased cortical neurons in the cranial cavity. However, the mechanisms underlying cortical folding remain largely unknown, mainly because genetic manipulations for the gyrencephalic brain have been unavailable. By combining in utero electroporation and the CRISPR/Cas9 system, we succeeded in efficient gene knockout of...

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PMID: 28854363
DOI: 10.1016/j.celrep.2017.08.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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