Article

Neural Progenitors as a Novel Pathogenic Mechanism in Microcephaly

2025-08-12

Abstract excerpt

Despite their significance, the genetic and molecular bases of neurodevelopmental disorders remain poorly understood. In this study, using human brain organoids and mouse models, we show that loss of NDE1 , a gene closely associated with microcephaly, disrupts progenitor identity, prolongs mitosis, and alters regional patterning in the forebrain. NDE1 knockout leads to a caudal identity shift of neural progenito...

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Literature Corpus work: 85bcf477-6612-5073-bfd2-96771c744451
DOI: 10.1101/2025.08.12.669854

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