Article

Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia

2019-10-29

Abstract excerpt

<h4>BACKGROUND and AIMS</h4> Extra-hepatic biliary atresia (BA) is a pediatric liver disease with no approved medical therapy. Recent studies using human samples and experimental modeling suggest that glutathione redox metabolism and heterogeneity play a role in disease pathogenesis. We sought to dissect the mechanistic basis of liver redox variation and explore how other stress responses affect cholangiocyte inj...

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Literature Corpus work: 8df581fb-9309-5035-acfc-8cb7addf40a6
DOI: 10.1101/821967

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