Article

IRE1α/XBP1 pathway expression is impaired in pediatric cholestatic liver disease explants

2022-03-12

Abstract excerpt

<h4>Background/Aims</h4> Cholestatic liver diseases (CLD) are the leading indication for pediatric liver transplantation. Increased intrahepatic bile acid concentrations cause endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) is activated to maintain homeostasis. UPR dysregulation, including the inositol-requiring enzyme 1α/X-box protein 1 (IRE1α/XBP1) pathway, is associated with several a...

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Literature Corpus work: 4893d298-482d-5e59-8cd3-74279f1704f7
DOI: 10.1101/2022.03.11.484034

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