Article

Modulation of the human cathelicidin dimerization interface separates antimicrobial activity from mammalian membrane disruption

2026-02-13

Abstract excerpt

The human CAMP gene product LL-37 is a prototypical cationic host defense peptide with potent activity against gram-negative bacteria. The development of LL-37 and other membrane-active host defense peptides as antibiotics, however, is limited in part by their activity against mammalian membranes. To better understand the structural features underlying LL-37 functions, we reconceived of LL-37 as a small protein a...

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Literature Corpus work: af8e0949-97d0-592a-bdb7-f4903862b81e
DOI: 10.64898/2026.02.13.705689

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