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Article

Separability of antibacterial and membranolytic activity in the human host defense peptide LL-37

2025-05-22

Abstract excerpt

<h4>Summary</h4> The human CAMP gene product LL-37 is thought to exert direct antimicrobial activity against gram-negative bacteria via membrane disruption. In the course of structure-activity relationship studies of LL-37 aimed at developing peptidomimetic antibiotics, however, we incidentally noted mutations in LL-37 that globally inhibit membrane disruption in both mammalian and gram-negative bacterial cells....

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Identifiers and source

Literature Corpus work
cdf8968d-017a-5937-9a54-242a63b085a4
DOI
10.1101/2025.05.22.655608
Open publication

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Separability of antibacterial and membranolytic activity in the human host defense peptide LL-37DOI 10.1101/2025.05.22.655608
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