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Article

Molecular interaction modes of the host-defense peptide cathelicidin LL-37 and its mutants dictate diverse antimicrobial activities.

Nanoscale - 7 May 2026

Jin Xiaofei, Wang Huipan, Tang Huayuan

Abstract excerpt

The host-defense peptide cathelicidin LL37 is an innate immune defense peptide with broad-spectrum antimicrobial effects. Experiments showed that the antimicrobial activity of LL37(17-29), the active core of LL37, was associated with peptide aggregation and fibrillization. Although wild-type (WT) LL37(17-29) aggregated into densely packed fibrils with strong antimicrobial activity, the F17S mutation exhibited a...

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PMID: 41945358
DOI: 10.1039/d5nr03981a

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DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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