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Article

Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37.

Antimicrobial agents and chemotherapy - 1 Feb 2012

Wang Guangshun, Epand Raquel F, Mishra Biswajit, Lushnikova Tamara, Thomas Vinai Chittezham, Bayles Kenneth W, Epand Richard M

Abstract excerpt

Human cathelicidin LL-37 is a critical cationic antimicrobial peptide for host defense against infection, immune modulation, and wound healing. This article elucidates the functional roles of the cationic side chains of the major antimicrobial region of LL-37, corresponding to residues 17 to 32 (designated GF-17). Antimicrobial assays, killing kinetics studies, and vesicle leakage experiments all indicate that a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22083479
DOI: 10.1128/AAC.05637-11
PMCID: PMC3264245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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