Article
Structure, dynamics, and antimicrobial and immune modulatory activities of human LL-23 and its single-residue variants mutated on the basis of homologous primate cathelicidins.
Biochemistry - 17 Jan 2012
Wang Guangshun, Elliott Melissa, Cogen Anna L, Ezell Edward L, Gallo Richard L, Hancock Robert E W
Abstract excerpt
LL-23 is a natural peptide corresponding to the 23 N-terminal amino acid residues of human host defense cathelicidin LL-37. LL-23 demonstrated, compared to LL-37, a conserved ability to induce the chemokine MCP-1 in human peripheral blood mononuclear cells, a lack of ability to suppress induction of the pro-inflammatory cytokine TNF-α in response to bacterial lipopolysaccharides (LPS), and reduced antimicrobial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.