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Article

Evolution of the primate cathelicidin. Correlation between structural variations and antimicrobial activity.

The Journal of biological chemistry - 21 Jul 2006

Zelezetsky Igor, Pontillo Alessandra, Puzzi Luca, Antcheva Nikolinka, Segat Ludovica, Pacor Sabrina, Crovella Sergio, Tossi Alessandro

Abstract excerpt

Cathelicidin genes homologous to the human CAMP gene, coding for the host defense peptide LL-37, have been sequenced and analyzed in 20 primate species, including Great Apes, hylobatidae, cercopithecidae, callithricidae, and cebidae. The region corresponding to the putative mature antimicrobial peptide is subject to a strong selective pressure for variation, with evidence for positive selection throughout the...

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Identifiers

PMID: 16720578
DOI: 10.1074/jbc.M511108200

Genes

CAMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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