Article

An M protein coiled coil unfurls and exposes its hydrophobic core to capture LL-37

2022-01-11

Abstract excerpt

<h4>ABSTRACT</h4> Surface-associated, coiled-coil M proteins of Streptococcus pyogenes (Strep A) disable human immunity through interaction with select proteins. However, coiled coils lack features typical of protein-protein interaction sites, and it is therefore challenging to understand how M proteins achieve specific binding, for example, with the human antimicrobial peptide LL-37, leading to its neutralizati...

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Literature Corpus work: df89f769-b695-55dd-92f3-42f427d48b8a
DOI: 10.1101/2022.01.11.475926

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