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Article

The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations.

Human molecular genetics - 4 Nov 2020

Chen Vivian, Moncalvo Malik, Tringali Dominic, Tagliafierro Lidia, Shriskanda Ahila, Ilich Ekaterina, Dong Wendy, Kantor Boris, Chiba-Falek Ornit

Abstract excerpt

Alpha-synuclein SNCA has been implicated in the etiology of Parkinson's disease (PD); however, the normal function of alpha-synuclein protein and the pathway that mediates its pathogenic effect is yet to be discovered. We investigated the mechanistic role of SNCA in the nucleus utilizing isogenic human-induced pluripotent stem cells-derived neurons from PD patients with autosomal dominant mutations, A53T and...

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Identifiers

PMID: 32954426
DOI: 10.1093/hmg/ddaa183
PMCID: PMC7645704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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