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Massive changes in gene expression and their cause(s) can be a unifying principle in the pathobiology of Alzheimer's disease

1 Feb 2025

Abstract excerpt

Understanding of the biology of Alzheimer's disease (AD) has long been fragmented, with various investigators concentrating on amyloid beta (Aβ) or tau, inflammation, cell death pathways, misfolded proteins, glia, and more. Yet data from multiple authors has repeatedly shown altered expression of myriad genes related to these seemingly disparate phenomena. In 2022, Morgan et al. organized the massive data on...

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PMID: 39912452
DOI: 10.1002/alz.14555

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