Article
From Common to Rare Variants: The Genetic Component of Alzheimer Disease.
Human heredity - 1 Jan 2016
Nicolas Gaël, Charbonnier Camille, Campion Dominique
Abstract excerpt
Alzheimer disease (AD) is a remarkable example of genetic heterogeneity. Extremely rare variants in the APP, PSEN1, or PSEN2 genes, or duplications of the APP gene cause autosomal dominant forms, generally with complete penetrance by the age of 65 years. Nonautosomal dominant forms are considered as a complex disorder with a high genetic component, whatever the age of onset. Although genetically heterogeneous, AD...
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