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An iron metabolism–senescence framework delineates a high-risk epithelial program associated with microenvironmental remodeling in clear cell renal cell carcinoma

2026-06-22

Abstract excerpt

<title>Abstract</title> <p> <bold>Purpose</bold> Clear cell renal cell carcinoma (ccRCC) shows marked malignant-cell heterogeneity and microenvironmental remodeling. This study aimed to develop an interpretable computational framework to examine whether iron metabolism and cellular senescence converge on a prognostically relevant epithelial program in ccRCC. <bold>Methods</bold> TCGA-KIRC bulk transcriptomic...

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Literature Corpus work
c6aff6f5-0291-5854-a8ed-4aa6f860deea
DOI
10.21203/rs.3.rs-9894257/v1
Open publication

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An iron metabolism–senescence framework delineates a high-risk epithelial program associated with microenvironmental remodeling in clear cell renal cell carcinomaDOI 10.21203/rs.3.rs-9894257/v1
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