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NETosis-based prognostic model reveals immune modulation in clear cell renal cell carcinoma using single-cell and bulk RNA sequencing

25 Jul 2025

Abstract excerpt

Further research is needed to investigate the association between netosis and clear cell renal cell carcinoma (ccRCC). We developed a prognostic framework for netosis using univariate, Lasso, and multivariate Cox regression analyses. The CIBERSORT algorithm was employed to compute immune infiltration metrics for The Cancer Genome Atlas (TCGA) dataset. These scores, combined with Cox regression analysis and...

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PMID: 40715295
DOI: 10.1038/s41598-025-11095-7

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