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Assessing the toxicological impact of DEHP exposure on IVDD through network toxicology, machine learning and multi-dimensional bioinformatics analysis

2026-05-12

Abstract excerpt

<b>Background: </b>Intervertebral disc degeneration (IVDD) is the leading cause of low back pain. Despite microplastic accumulation in human discs, the molecular role of the plasticiser DEHP in IVDD remains systematically underexplored. <b>Methods: </b>DEHP and IVDD targets were retrieved from databases including ChEMBL, GeneCards, and OMIM. Following enrichment analysis, common targets were intersected with GSE56...

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Literature Corpus work
af56c520-11d2-556f-96f4-fdf3582517e8
DOI
10.22541/authorea.15003038/v1
Open publication

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Assessing the toxicological impact of DEHP exposure on IVDD through network toxicology, machine learning and multi-dimensional bioinformatics analysisDOI 10.22541/authorea.15003038/v1
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