Back to search

Article

Identification and experimental validation of biomarkers associated with exercise in intervertebral disc degeneration through bulk RNA and single-cell RNA sequencing analysis

2026-02-02

Abstract excerpt

<title>Abstract</title> <p>Background Long-term running positively impacts the intervertebral disc. This study aimed to ascertain and validate biomarkers linked to exercise-related genes (ERGs) in intervertebral disc degeneration (IDD), potentially guiding the development of targeted therapies. Methods In this study, IDD related datasets and ERGs were mined from public databases. Biomarkers were ascertained thr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e47cdaaf-8b5d-5e64-bf38-9d4072767874
DOI
10.21203/rs.3.rs-8535545/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Identification and experimental validation of biomarkers associated with exercise in intervertebral disc degeneration through bulk RNA and single-cell RNA sequencing analysisDOI 10.21203/rs.3.rs-8535545/v1
Identification of Biomarkers in Intervertebral Disc Degeneration Using Bioinformatics and Machine Learning AlgorithmsSemantic proximity
Study on molecular mechanism of intervertebral disc degeneration by single cell hdWGCNA combined with transcriptome sequencingSemantic proximity
Identification of Core Genes and Screening of Potential Targets in Intervertebral Disc Degeneration Using Integrated Bioinformatics AnalysisSemantic proximity
Identification and experimental verification of biomarkers related to metal ion transport in intervertebral disc degenerationSemantic proximity
GREM1,LRPPRC and SLC39A4 as Potential Biomarkers of Intervertebral Disc Degeneration:A Bioinformatics Analysis based on Multiple Microarray and Single-cell Sequencing DataSemantic proximity
A diagnostic signatures for intervertebral disc degeneration using TNFAIP6 and COL6A2 based on single-cell RNA-seq and bulk RNA-seq analysesSemantic proximity
Identification of core genes in intervertebral disc degeneration using bioinformatics and machine learning algorithmsSemantic proximity
Deciphering the sequential changes of monocytes/macrophages in the progression of IDD with longitudinal approach using single-cell transcriptomeSemantic proximity
Bioinformatics-Based Discovery of Intervertebral Disc Degeneration Biomarkers and Immune- Inflammatory InfiltratesSemantic proximity
Single-Cell and WGCNA Integrative Analysis Reveal the Key Chondrocytes Niches and Pathogenic Genes in Intervertebral Disc DegenerationSemantic proximity
Significance of oxidative stress in the diagnosis and subtype classification of intervertebral disc degenerationSemantic proximity
RRM2: a crosstalk gene for COVID-19 and intervertebral disc degeneration revealed by integrated WGCNA and machine learningSemantic proximity
Select a neighboring publication to make it the new centre.