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Article

Glycolytic metabolic reprogramming and mitochondrial dysfunction: A novel mechanism underlying PAEs-promoted cartilage inflammatory phenotype.

Ecotoxicology and environmental safety - 15 Mar 2026

Liu Lu, Chen Yongchang, Lin Wenying, Zheng Mian, Yu Tianqi, Chen Ruyan, Yang Yanru, Jiao Lingling, Ruan Qinli, Sun Jia

Abstract excerpt

Phthalate esters (PAEs), the most prevalent class of plasticizers, are widely acknowledged as environmental endocrine disruptors (EDCs) and have been linked to the pathogenesis of various diseases. However, their specific role and intrinsic mechanism in inducing cartilage damage in bone-related diseases remain unclear. This study aimed to clarify the correlation between PAEs and cartilage damage, and to explore...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41833247
DOI: 10.1016/j.ecoenv.2026.120027

Genes

CASP3
BCL2
EGFR
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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