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Article

Dynamic transition of Tregs to cytotoxic phenotype amid systemic inflammation in Graves' ophthalmopathy.

JCI insight - 22 Nov 2024

Liu Zhong, Ke Shu-Rui, Shi Zhuo-Xing, Zhou Ming, Sun Li, Sun Qi-Hang, Xiao Bing, Wang Dong-Liang, Huang Yan-Jin, Lin Jin-Shan, Wang Hui-Shi, Zhang Qi-Kai, Pan Cai-Neng, Liang Xuan-Wei, Chen Rong-Xin, Mao Zhen, Lin Xian-Chai

Abstract excerpt

Graves' disease (GD) is an autoimmune condition that can progress to Graves' ophthalmopathy (GO), leading to irreversible damage to orbital tissues and potential blindness. The pathogenic mechanism is not fully understood. In this study, we conducted single-cell multi-omics analyses on healthy individuals, patients with GD without GO, newly diagnosed patients with GO, and treated patients with GO. Our findings...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39365735
DOI: 10.1172/jci.insight.181488
PMCID: PMC11601897

Genes

TSHR
YY1

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