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Integrative transcriptomic profiling and machine learning reveal hypoxia-associated molecular signatures for precision diagnosis in thyroid eye disease

24 Nov 2025

Abstract excerpt

BACKGROUND: Thyroid eye disease (TED) is an autoimmune disorder characterized by persistent inflammation around the periphery and within the orbit, potentially driven by hypoxic conditions. Effective biomarkers and precise predictive models are still lacking for the early diagnosis of TED. METHODS: Bulk RNA sequencing was conducted on peripheral blood samples from TED patients, Graves' hyperthyroidism (GH)...

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PMID: 41287009
DOI: 10.1186/s40246-025-00860-4

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