Article

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

2024-04-21

Abstract excerpt

Despite recent advances in the treatment of thyroid eye disease (TED), significant gaps remain in our understanding of the underlying molecular mechanisms, particularly concerning the insulin-like growth factor-1 receptor (IGF-1R) pathway. To dissect the pathophysiology of TED, we utilized single nucleus RNA-Seq to analyze orbital fat specimens from both TED patients and matched controls. The analysis demonstrated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 30041a5e-0e23-58a7-a015-449a595297c5
DOI: 10.1101/2024.04.19.590238

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R PathwayDOI 10.1101/2024.04.19.590238Read

Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathwaySemantic proximity Read

Transcriptomic profiling of human orbital fat and differentiating orbital fibroblastsSemantic proximity Read

Exploring Prognostic Gene Expression Signature for Thyroid Eye DiseaseSemantic proximity Read

Transcriptome-level microarray expression profiling implicates IGF-1 and Wnt signalling dysregulation in the pathogenesis of thyroid-associated orbitopathySemantic proximity Read

Novel insights into the pathogenesis of thyroid eye disease through ferroptosis-related gene signature and immune infiltration analysisSemantic proximity Read

miR-101-3p suppresses proliferation of orbital fibroblasts by targeting pentraxin-3 in thyroid eye diseaseSemantic proximity Read

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fibroblasts Identifies Sorafenib as a Novel TherapeuticSemantic proximity Read

A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves' orbitopathy.Semantic proximity Read

Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy.Semantic proximity Read

Integrative transcriptomic profiling and machine learning reveal hypoxia-associated molecular signatures for precision diagnosis in thyroid eye diseaseSemantic proximity Read

Unravelling the pathogenic mechanisms in Graves’ orbitopathySemantic proximity Read

Cigarette Smoking Drives Thyroid Eye Disease Progression via RAGE Signaling ActivationSemantic proximity Read