Menin inhibition impairs metastatic colonization of Ewing sarcoma

Abstract excerpt

Menin is a scaffolding protein that interacts with context-specific partners to regulate gene expression. In MLL-rearranged leukemias, Menin:MLL interactions drive leukemogenesis and Menin inhibitors have been FDA approved for these cancers. We previously reported that Menin promotes oncogenic phenotypes in Ewing sarcoma (EwS). Here, we sought to define EwS-specific functions of Menin and determine if Menin inhibi...

Topics

Open a Topic to create a Post that cites this publication.

• Acute Myeloid Leukemia Research
• Cell Line, Transformed
• Chromatin Immunoprecipitation
• Chromatin Remodeling and Cancer
• Genomics and Chromatin Dynamics
• Histone Deacetylase Inhibitors Research
• Neuroendocrine Tumor Research Advances
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

af3690a6-b0f4-5698-8cf2-c7fb640a426c

DOI

10.1101/2025.11.10.687648