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Article

Trehalose is required for growth of Mycobacterium smegmatis.

The Journal of biological chemistry - 9 Jul 2004

Woodruff Peter J, Carlson Brian L, Siridechadilok Bunpote, Pratt Matthew R, Senaratne Ryan H, Mougous Joseph D, Riley Lee W, Williams Spencer J, Bertozzi Carolyn R

Abstract excerpt

Mycobacteria contain high levels of the disaccharide trehalose in free form as well as within various immunologically relevant glycolipids such as cord factor and sulfolipid-1. By contrast, most bacteria use trehalose solely as a general osmoprotectant or thermoprotectant. Mycobacterium tuberculosis and Mycobacterium smegmatis possess three pathways for the synthesis of trehalose. Most bacteria possess only one...

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Identifiers

PMID: 15102847
DOI: 10.1074/jbc.M313103200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Trehalose is required for growth of Mycobacterium smegmatis.PMID 15102847Read ↗

Genetics of Mycobacterial Trehalose MetabolismSemantic proximity Read ↗

Exquisite specificity of Pks13 defines the essentiality of trehalose in mycobacteriaSemantic proximity Read ↗

The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapiesSemantic proximity Read ↗

Targeting trehalose and methylglucose lipopolysaccharide biosynthetic pathways in M. tuberculosis : structural and functional characterisation, and early-stage drug discovery of OtsA and Rv3030Semantic proximity Read ↗

FbpA-Dependent biosynthesis of trehalose dimycolate is required for the intrinsic multidrug resistance, cell wall structure, and colonial morphology of Mycobacterium smegmatis.Semantic proximity Read ↗

The crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in Corynebacterineae.Semantic proximity Read ↗

MtrP, a putative methyltransferase in Corynebacteria, is required for optimal membrane transport of trehalose mycolates.Semantic proximity Read ↗

Identification of M. tuberculosis Rv3441c and M. smegmatis MSMEG_1556 and essentiality of M. smegmatis MSMEG_1556.Semantic proximity Read ↗

Inactivation of tesA Reduces Cell Wall Lipid Production and Increases Drug Susceptibility in MycobacteriaSemantic proximity Read ↗

Trehalose synthase converts glycogen to trehalose.Semantic proximity Read ↗

Therapeutically useful mycobacteriophages BPs and Muddy require trehalose polyphleatesSemantic proximity Read ↗

MSMEG_5684 down-regulation in Mycobacterium smegmatis affects its permeability, survival under stress and persistence.Semantic proximity Read ↗

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