Article

The gut microbiota promotes liver regeneration through hepatic membrane phospholipid synthesis

2022-08-26

Abstract excerpt

<h4>Background & Aims</h4> Hepatocyte growth and proliferation is dependent on the synthesis of membrane phospholipids. Lipid synthesis, in turn, requires short chain fatty acids (SCFA) generated by bacterial fermentation, delivered through the gut- liver axis. We therefore hypothesized that dysbiotic insults like antibiotics treatment not only negatively affect gut microbiota, but also impair hepatic lipid synth...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 24bbe261-2db8-589f-ae5f-fb49866714b2
DOI: 10.1101/2022.08.25.505228

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The gut microbiota promotes liver regeneration through hepatic membrane phospholipid synthesisDOI 10.1101/2022.08.25.505228Read

Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease: Current Progress and ChallengesSemantic proximity Read

Bridging the Gut and Liver: Multi-biotics modulate microbiota composition and corroborate transcriptomic improvements in MASLDSemantic proximity Read

Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatmentSemantic proximity Read

NAFLD/MASLD and the Gut–Liver Axis: From Pathogenesis to Treatment OptionsSemantic proximity Read

The role of microbiota in nonalcoholic fatty liver disease: mechanism of action and treatment strategySemantic proximity Read

Chenodeoxycholic Acid Modulation via <i>Bacteroides intestinalis</i> AM1 underscores a Novel Approach in Acute Liver FailureSemantic proximity Read

Single cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a pro-inflammatory metabolic signature in male mice at late adulthoodSemantic proximity Read

Host hepatic metabolism is modulated by gut microbiota-derived sphingolipidsSemantic proximity Read

Recent Trends of Microbiota-Based Microbial Metabolites Metabolism in Liver DiseaseSemantic proximity Read

A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non‐Alcoholic Fatty Liver DiseaseSemantic proximity Read

Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatmentSemantic proximity Read

Gut dysbiosis protects against liver injury in autophagy deficient mice by FXR-FGF15 feedback signalingSemantic proximity Read