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Article

Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway.

Molecular and cellular endocrinology - 20 Aug 2020

Han Xiqiong, Ma Wenqi, Zhu Yi, Sun Xuejiao, Liu Naifeng

Abstract excerpt

Atherosclerotic plaque rupture followed by luminal thrombosis is recognized as the main cause of acute cardiovascular events, especially in patients with diabetes. Although previous studies identified stimulation of macrophages polarization with advanced glycation end products (AGEs) results in the rapid progression of atherosclerosis, the underlying mechanisms are not understood fully. The purpose of this study...

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Identifiers

PMID: 32464167
DOI: 10.1016/j.mce.2020.110878

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