Article

TAK1 blockade as a therapy for retinal neovascularization

2021-01-29

Abstract excerpt

<h4>ABSTRACT</h4> Retinal neovascularization, or pathological angiogenesis in the retina, is a leading cause of blindness in developed countries. Transforming growth factor-β-activated kinase 1 (TAK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) activated by TGF-β1 and other pro-inflammatory cytokines. TAK1 is also a key mediator of inflammation, innate immune responses, apoptosis and tissue homeo...

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Literature Corpus work: ada32dcd-3d15-5a94-977e-7451f7e7e680
DOI: 10.1101/2021.01.29.428701

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