Article

Tissues Guide Dependence of Treg on the Transferrin Receptor

2026-02-03

Abstract excerpt

Activated T cells increase transferrin-bound iron uptake via the transferrin receptor, also called CD71. We previously demonstrated that targeting CD71 with an antibody to reduce iron update can modify CD4 T cell function, with different effects on T H 1, T H 17, and regulatory T (Treg) cells. CD71 blocking antibody-treated Tregs had no loss of viability or differentiation, and Foxp3 expression was increased. Ho...

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Literature Corpus work: af1398dd-e265-55c1-ac98-591e7514ef51
DOI: 10.64898/2026.02.01.703140

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