Article

NRF1 Predominantly Causes EZH2 Overexpression in Cancer Cells

2025-10-06

Abstract excerpt

<title>Abstract</title> <p>EZH2 is an oncogene and therapeutic target. Only a small proportion of cancer patients benefit from treatment with EZH2 inhibitors (EZH2is). The mechanisms underlying EZH2 overexpression and EZH2i resistance are not clear. Here, we reported that the nuclear respiratory factor 1 gene (<italic>NRF1</italic>) is the gene whose expression is most strongly correlated with that of the <italic...

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Literature Corpus work: aefe5eef-35e6-55fd-bbc2-c1ec653e5c74
DOI: 10.21203/rs.3.rs-7217912/v1

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