Article
Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.
Neuro-oncology - 1 Apr 2015
Kanamori Masayuki, Higa Tsuyoshi, Sonoda Yukihiko, Murakami Shohei, Dodo Mina, Kitamura Hiroshi, Taguchi Keiko, Shibata Tatsuhiro, Watanabe Mika, Suzuki Hiroyoshi, Shibahara Ichiyo, Saito Ryuta, Yamashita Yoji, Kumabe Toshihiro, Yamamoto Masayuki, Motohashi Hozumi, Tominaga Teiji
Abstract excerpt
BACKGROUND: Nuclear factor erythroid 2-related factor 2 (NRF2) plays pivotal roles in cytoprotection. We aimed at clarifying the contribution of the NRF2 pathway to malignant glioma pathology. METHODS: NRF2 target gene expression and its association with prognosis were examined in 95 anaplastic gliomas with or without isocitrate dehydrogenase (IDH) 1/2 gene mutations and 52 glioblastomas. To explore mechanisms...
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