Article

Nrf1 is endowed with a dominant tumor-repressing effect onto the Wnt/β-Catenin-dependent and -independent signaling networks in the human liver cancer

2019-08-05

Abstract excerpt

<h4>ABSTRACT</h4> Our previous work revealed that Nrf1α exerts a tumor-repressing effect because its genomic loss (to yield Nrf1α −/− ) results in oncogenic activation of Nrf2 and target genes. Interestingly, β-catenin is concurrently activated by loss of Nrf1α in a way similar to β-catenin-driven liver tumor. However, a presumable relationship between Nrf1 and β-catenin is not as yet established. Here, we demon...

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Literature Corpus work: 9ed55d83-729f-5620-a219-8a29c69850cd
DOI: 10.1101/726349

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