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Article

Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis.

Journal of the American Chemical Society - 15 Feb 2012

Feng Zhiyang, Chakraborty Debjani, Dewell Scott B, Reddy Boojala Vijay B, Brady Sean F

Abstract excerpt

In a recent study of polyketide biosynthetic gene clusters cloned directly from soil, we isolated two antibiotics, fasamycins A and B, which showed activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. To identify the target of the fasamycins, mutants with elevated fasamycin A minimum inhibitory concentrations were selected from a wild-type culture of E....

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Identifiers

PMID: 22224500
DOI: 10.1021/ja207662w
PMCID: PMC3335777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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