Article

TLR7 Variants Enhance Responsiveness and Broaden RNA Specificity To Drive Human Lupus

2025-11-13

Abstract excerpt

Dysregulated nucleic acid sensing underlies lethal viral infections and autoimmunity. Endosomal Toll-like receptor 7 (TLR7) recognizes guanosine and oligoribonucleotides (ORNs) from single-stranded RNA via two ligand-binding sites in its leucine-rich repeat (LRR) ectodomain. Recent genetic studies have demonstrated that TLR7 gain-of-function (GOF) variants cause childhood lupus or immune thrombocytopenic purpura...

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Literature Corpus work: 596805b5-da63-5743-9b1c-ec13d38998b2
DOI: 10.1101/2025.11.07.25338211

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