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Gene–Dose–Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer’s Mice

2024-02-29

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is a major progressive neurodegenerative disorder of the aging population. High post–menopausal levels of the pituitary gonadotropin follicle–stimulating hormone (FSH) are strongly associated with the onset of AD, and we have shown recently that FSH directly activates the hippocampal <italic>Fshr</italic> to drive AD–like pathology and memory loss in mice. To es...

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Literature Corpus work
aec75a94-e54e-52c7-a03a-2da0a29cc8ea
DOI
10.21203/rs.3.rs-3964789/v1
Open publication

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Gene–Dose–Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer’s MiceDOI 10.21203/rs.3.rs-3964789/v1
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