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Article

Activation of estrogen receptor α increases and estrogen receptor β decreases apolipoprotein E expression in hippocampus <i>in vitro</i> and <i>in vivo</i>

2 Nov 2006

Abstract excerpt

Previous evidence indicates that, in carriers of apolipoprotein E4 (ApoE4), estrogen therapy increased the risk of late-onset Alzheimer's disease (AD), whereas in individuals carrying ApoE2/3, estrogen therapy reduced the risk of AD [Cauley JA, Zmuda JM, Yaffe K, Kuller LH, Ferrell RE, Wisniewski SR, Cummings SR (1999) J Bone Miner Res 14:1175-1181; Yaffe K, Haan M, Byers A, Tangen C, Kuller L (2000) Neurology...

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Identifiers

PMID: 17077142
DOI: 10.1073/pnas.0608128103

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