Article

Haploinsufficiency of lysosomal enzyme genes in Alzheimer’s disease

2024-11-18

Abstract excerpt

There is growing evidence suggesting that the lysosome or lysosome dysfunction is associated with Alzheimer’s disease (AD). Pathway analysis of post mortem brain-derived proteomic data from AD patients shows that the lysosomal system is perturbed relative to similarly aged unaffected controls. However, it is unclear if these changes contributed to the pathogenesis or are a response to the disease. Consistent with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aec6611f-b2dc-5427-b075-9deae71ff705
DOI: 10.1101/2024.11.16.623962

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Haploinsufficiency of lysosomal enzyme genes in Alzheimer’s diseaseDOI 10.1101/2024.11.16.623962Read

Neurodegenerative lysosomal disorders: A continuum from development to late ageSemantic proximity Read

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein mediated neurodegenerationSemantic proximity Read

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicitySemantic proximity Read

Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Semantic proximity Read

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosisSemantic proximity Read

Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's diseaseSemantic proximity Read

Investigating the Endo-Lysosomal System in Major Neurocognitive Disorders Due to Alzheimer's Disease, Frontotemporal Lobar Degeneration and Lewy Body Disease: Evidence for SORL1 as a Cross-Disease Gene.Semantic proximity Read

Defective Lysosomal Lipid Catabolism as a Common Pathogenic Mechanism for Dementia.Semantic proximity Read

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunctionSemantic proximity Read

Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson’s diseaseSemantic proximity Read

The role of Alzheimer's disease risk genes in endolysosomal pathways.Semantic proximity Read

Unifying biology of neurodegeneration in lysosomal storage diseasesSemantic proximity Read