Article

Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson’s disease

2026-02-18

Abstract excerpt

Lysosomal dysfunction is central to Parkinson’s disease pathogenesis, with GBA1 as the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid and ceramide metabolism have been proposed as contributors to Parkinson’s disease, underscoring the need for comprehensive genetic analyses across these pathways. We analysed rare variants (minor allele frequenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d8ec51b9-ce8f-5bca-893b-8e4bd885a1b7
DOI: 10.64898/2026.02.18.26346391

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson’s diseaseDOI 10.64898/2026.02.18.26346391Read

Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease.Semantic proximity Read

Role of Lysosomal Gene Variants in Modulating GBA-Associated Parkinson's Disease Risk.Semantic proximity Read

Rare Variants in Specific Lysosomal Genes Are Associated With Parkinson's Disease.Semantic proximity Read

Large-scale rare variant burden testing in Parkinson's disease.Semantic proximity Read

The Association Between Lysosomal Storage Disorder Genes and Parkinson’s Disease: A Large Cohort Study in Chinese Mainland PopulationSemantic proximity Read

Large-scale Rare Variant Burden Testing in Parkinson’s Disease Identifies Novel Associations with Genes Involved in Neuro-inflammationSemantic proximity Read

Exome sequencing in Asian populations identifies rare deficientSMPD1alleles that increase risk of Parkinson’s diseaseSemantic proximity Read

Association of Rare Variants in ARSA with Parkinson's DiseaseSemantic proximity Read

Whole-genome sequencing of 197 cases with Parkinson’s Disease reveals novel pathogenic variants in the Indian populationSemantic proximity Read

Penetrance of Parkinson’s disease inGBA1carriers is depending on the variant severity and polygenic backgroundSemantic proximity Read

Targeted sequencing of Parkinson’s disease loci genes highlightsSYT11, FGF20and other associationsSemantic proximity Read

Rare-Variant Burden Analysis of Dystonia Genes in Parkinson’s DiseaseSemantic proximity Read