Article
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.
Nature medicine - 1 Jan 2015
Linnemann Carsten, van Buuren Marit M, Bies Laura, Verdegaal Els M E, Schotte Remko, Calis Jorg J A, Behjati Sam, Velds Arno, Hilkmann Henk, Atmioui Dris El, Visser Marten, Stratton Michael R, Haanen John B A G, Spits Hergen, van der Burg Sjoerd H, Schumacher Ton N M
Abstract excerpt
Tumor-specific neo-antigens that arise as a consequence of mutations are thought to be important for the therapeutic efficacy of cancer immunotherapies. Accumulating evidence suggests that neo-antigens may be commonly recognized by intratumoral CD8+ T cells, but it is unclear whether neo-antigen-specific CD4+ T cells also frequently reside within human tumors. In view of the accepted role of tumor-specific CD4+...
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