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Article

HLA class I loss in metachronous metastases prevents continuous T cell recognition of mutated neoantigens in a human melanoma model.

Oncotarget - 25 Apr 2017

Schrörs Barbara, Lübcke Silke, Lennerz Volker, Fatho Martina, Bicker Anne, Wölfel Catherine, Derigs Patrick, Hankeln Thomas, Schadendorf Dirk, Paschen Annette, Wölfel Thomas

Abstract excerpt

T lymphocytes against tumor-specific mutated neoantigens can induce tumor regression. Also, the size of the immunogenic cancer mutanome is supposed to correlate with the clinical efficacy of checkpoint inhibition. Herein, we studied the susceptibility of tumor cell lines from lymph node metastases occurring in a melanoma patient over several years towards blood-derived, neoantigen-specific CD8+ T cells. In...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitope Mapping

Share to Epitopes, T-Lymphocyte

Share to Genes, MHC Class I

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Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Cell Antigen Receptor Specificity

Source

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Identifiers

PMID: 28423700
DOI: 10.18632/oncotarget.16048
PMCID: PMC5438652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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