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Article

Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division.

The Journal of biological chemistry - 17 Dec 2004

Izumikawa Tomomi, Kitagawa Hiroshi, Mizuguchi Souhei, Nomura Kazuko H, Nomura Kazuya, Tamura Jun-Ichi, Gengyo-Ando Keiko, Mitani Shohei, Sugahara Kazuyuki

Abstract excerpt

Chondroitin polymerization was first demonstrated in vitro when human chondroitin synthase (ChSy) was coexpressed with human chondroitin polymerizing factor (ChPF), which is homologous to ChSy but has little glycosyltransferase activity. To analyze the biological function of chondroitin, the Caenorhabditis elegans ortholog of human ChSy (sqv-5) was recently cloned, and the expression of its product was depleted...

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PMID: 15485872
DOI: 10.1074/jbc.M409615200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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