Article

Structure of the human heparan-α-glucosaminide <i>N</i> -acetyltransferase (HGSNAT)

2023-10-25

Abstract excerpt

Degradation of heparan sulfate (HS), a glycosaminoglycan (GAG) comprised of repeating units of N -acetylglucosamine and glucuronic acid, begins in the cytosol and is completed in the lysosomes. Acetylation of the terminal non-reducing amino group of α-D-glucosamine of HS is essential for its complete breakdown into monosaccharides and free sulfate. Heparan-α-glucosaminide N -acetyltransferase (HGSNAT), a residen...

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Literature Corpus work: b3e5ee3f-69f0-5fc5-bed2-d71576640fc4
DOI: 10.1101/2023.10.23.563672

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