Article

Activity-dependent COX-2 proteolysis generates a catalytically inactive fragment that affects aerobic respiration and proliferation

2024-04-11

Abstract excerpt

<h4>Summary</h4> Cyclooxygenase-2 (COX-2) catalyzes arachidonic acid (AA) into PGH 2 , the single source of all prostaglandins (PGs), ligands that activate multiple inflammatory pathways. AA catalysis quickly results in suicide inactivation, rendering the enzyme catalytically inactive. We show that the catalytic activity also leads to controlled cleavage of COX-2, an event that is differentially regulated by fat...

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Literature Corpus work: ae92b00d-d46a-5125-870b-b1f6ad4188e9
DOI: 10.1101/2024.04.08.588559

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