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Article

The N-terminus of COX-1 and its effect on cyclooxygenase-1 catalytic activity.

Journal of genetics and genomics = Yi chuan xue bao - 1 Feb 2010

Xu Yibing, Phipps Sean, Turner Michael J, Simmons Daniel L

Abstract excerpt

Cyclooxygenases are encoded by COX-1 and COX-2. They share over sixty percent sequence identity in human and are similar to each other in their crystallographic structures. One major difference in the primary structure of these two isozymes is the presence of eight amino acids in the amino-terminal region of COX-1 that are not present in COX-2. The function of this amino acid sequence is unknown. In this study, a...

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PMID: 20227045
DOI: 10.1016/S1673-8527(09)60030-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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