Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct functions of COX-1 and COX-2.

Prostaglandins & other lipid mediators - 1 Aug 2002

Morita Ikuo

Abstract excerpt

The enzymes that convert arachidonic acid to prostaglandin H2 are named cyclooxygenase-1 (COX-1) and COX-2. The properties of COX-1 are different from those of COX-2. It was originally thought that the function of COX-1 was involved in physiological phenomena, whereas that of COX-2 was involved in various pathologies. However, studies with COX-2 knockout mouse suggest that COX-2 also plays important roles in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular System
Share to Cyclooxygenase 1
Share to Cyclooxygenase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isoenzymes

Share to Kidney

Share to Prostaglandin-Endoperoxide Synthases

Share to Prostaglandins

Share to Tissue Distribution

Source

Identifiers

PMID: 12432916
DOI: 10.1016/s0090-6980(02)00029-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct functions of COX-1 and COX-2.PMID 12432916Read ↗

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.Semantic proximity Read ↗

Function of COX-2 and Prostaglandins in Neurological DiseaseSemantic proximity Read ↗

[Cyclooxygenase 2 and carcinogenesis].Semantic proximity Read ↗

Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.Semantic proximity Read ↗

Cyclooxygenase-deficient mice. A summary of their characteristics and susceptibilities to inflammation and carcinogenesis.Semantic proximity Read ↗

Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesisSemantic proximity Read ↗

Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implicationsSemantic proximity Read ↗

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?Semantic proximity Read ↗

Role of Cyclooxygenase-2 in Head and Neck Tumorigenesis.Semantic proximity Read ↗

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions.Semantic proximity Read ↗

Studying COX-2 in the cardiovascular system using a transcriptomic approachSemantic proximity Read ↗

Developmental expression of functional cyclooxygenases in zebrafishSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.