Article

Studying COX-2 in the cardiovascular system using a transcriptomic approach

2018-01-01

Abstract excerpt

At the time of starting my thesis there were no agreed mechanisms that could explain how cyclooxygenase (COX)-2 protects the cardiovascular system and no ‘hypothesis generating’ approaches done to try to find new answers. I have used transcriptomics, to come up with targets for this problem. I used microarray and RNA-seq on the following experimental models; (i) tissue from COX-1/COX-2 knockout mice, (ii) wildtype...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e3716de-3c80-5039-85b4-b989c20e96fa
DOI: 10.25560/83001

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Studying COX-2 in the cardiovascular system using a transcriptomic approachDOI 10.25560/83001Read

Metabolomic insights into the pharmacological and genetic inhibition of cyclooxygenase-2Semantic proximity Read

Distinct functions of COX-1 and COX-2.Semantic proximity Read

Complexity of <i>COX</i>-<i>2</i> gene regulationSemantic proximity Read

Congestive heart failure in COX2 deficient rats.Semantic proximity Read

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?Semantic proximity Read

Developmental expression of functional cyclooxygenases in zebrafishSemantic proximity Read

[Cyclooxygenase 2 and carcinogenesis].Semantic proximity Read

Suppression of cyclooxygenase-2 predisposes to heart failure with preserved ejection fractionSemantic proximity Read

Differential gene expression profiling in genetic and multifactorial cardiovascular diseasesSemantic proximity Read

Transcriptomic biomarkers of cardiovascular disease.Semantic proximity Read

Differentially expressed genes and canonical pathways in the ascending thoracic aortic aneurysm – The Tampere Vascular StudySemantic proximity Read

PACER lncRNA regulates COX-2 expression in lung cancer cellsSemantic proximity Read