Back to search

Article

Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways

2021-06-12

Abstract excerpt

<h4>Background</h4> Mutations and multiplications in the gene encoding for alpha-synuclein are associated with Parkinson’s disease (PD). However, not all individuals with alpha-synuclein variants develop PD, suggesting that additional factors are involved. We hypothesized that increased alpha-synuclein might alter epigenetic regulation of PD pathways. <h4>Objectives</h4> To identify genome-wide DNA methylation a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ae763a03-e5c4-5c2f-8ff9-53bb215e8b34
DOI
10.1101/2021.06.12.448150
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathwaysDOI 10.1101/2021.06.12.448150
The yin and yang of α-synuclein-associated epigenetics in Parkinson’s diseaseSemantic proximity
Deregulation of α-synuclein in Parkinson’s disease: Insight from epigenetic structure and transcriptional regulation of SNCASemantic proximity
CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease.Semantic proximity
α-Synuclein and Mechanisms of Epigenetic RegulationSemantic proximity
L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro.Semantic proximity
Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body DiseaseSemantic proximity
[Neurodegeneration and epigenetics].Semantic proximity
Global Effects of a PD Risk-SNP at the Alpha-Synuclein LocusSemantic proximity
Advancing Stem Cell Models of Alpha-Synuclein Gene Regulation in Neurodegenerative DiseaseSemantic proximity
Parkinson's disease correlates with promoter methylation in the α-synuclein gene.Semantic proximity
Epigenetic regulation in Parkinson's disease.Semantic proximity
Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.Semantic proximity
Select a neighboring publication to make it the new centre.