Article

The kinase Isr1 negatively regulates hexosamine biosynthesis in <i>S. cerevisiae</i>

2020-04-24

Abstract excerpt

The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP), which converts glucose into uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), the carbohydrate precursor to protein glycosylation, GPI-anchor formation, and chitin biosynthesis. Overexpression of ISR1 is lethal and...

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Literature Corpus work: ae4fca52-adde-570b-8dd0-e55f821d8b50
DOI: 10.1101/2020.04.22.055699

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