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Article

The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae.

PLoS genetics - 1 Jun 2020

Alme Emma B, Stevenson Erica, Krogan Nevan J, Swaney Danielle L, Toczyski David P

Abstract excerpt

The S. cerevisiae ISR1 gene encodes a putative kinase with no ascribed function. Here, we show that Isr1 acts as a negative regulator of the highly-conserved hexosamine biosynthesis pathway (HBP), which converts glucose into uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), the carbohydrate precursor to protein glycosylation, GPI-anchor formation, and chitin biosynthesis. Overexpression of ISR1 is lethal and,...

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Identifiers

PMID: 32579556
DOI: 10.1371/journal.pgen.1008840
PMCID: PMC7340321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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