Article
Structural basis for Fc gammaRIIa recognition of human IgG and formation of inflammatory signaling complexes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2011
Ramsland Paul A, Farrugia William, Bradford Tessa M, Sardjono Caroline Tan, Esparon Sandra, Trist Halina M, Powell Maree S, Tan Peck Szee, Cendron Angela C, Wines Bruce D, Scott Andrew M, Hogarth P Mark
Abstract excerpt
The interaction of Abs with their specific FcRs is of primary importance in host immune effector systems involved in infection and inflammation, and are the target for immune evasion by pathogens. FcγRIIa is a unique and the most widespread activating FcR in humans that through avid binding of immune complexes potently triggers inflammation. Polymorphisms of FcγRIIa (high responder/low responder [HR/LR]) are...
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